Radiolabelling is a cornerstone technique in drug metabolism and pharmacokinetics (DMPK) studies for tracking a drug’s journey through the body, providing essential data to inform critical decisions during drug development. For over 50 years, Nuvisan has specialised in radiolabelling of NCEs (³H, ¹⁴C) and synthesis of stable isotope-labelled NCEs (²H, ¹³C, ¹⁵N). Our expertise and state-of-the-art capabilities enable precise, high-quality results, helping accelerate your research and development process with tailored solutions for even the most complex requirements.
Stable isotope synthesis (2H, 13C, 15N)
Stable isotope-labelled compounds are used as internal standards in bioanalysis to control for extraction, ionisation and injection variability, making them essential for robust mass spectrometric analysis. We have successfully delivered stable isotope-labelled molecules from a diverse spectrum of compound classes, including small molecules, peptides, carbohydrates, lipids and more.
Radioactive isotope synthesis (14C)
The rationale for selecting carbon-14 in the radiolabelling of compounds lies in its ability to substitute specific carbon-12 atoms, producing chemically identical analogues. Before synthesis, we identify an appropriate position for the radioactive label that is expected to be chemically and metabolically stable. Incorporating carbon-14 into the target molecule requires total synthesis from basic precursors such as 14C-cyanide. By applying the latest methods and techniques, including enantioselective synthesis and chiral separation, we can synthesise almost any achiral or chiral chemical compound. All radiolabelled compounds are released with a comprehensive certificate of analysis (CoA), detailing chemical and radiochemical purity, as well as enantiomeric purity (if applicable).
Radioanalytical and purification services
We analyse your radiolabelled compound using state-of-the-art methods and equipment to assess radiochemical purity, specific activity and stability. Employing high-efficiency separation techniques, we purify radiolabelled compounds to remove impurities and by-products, helping ensure the highest quality material for your experiments and studies.
Compound storage solutions
Nuvisan provides safe storage of radiolabelled material at various temperatures in a controlled and monitored environment. Worldwide shipment is arranged by personnel trained in Good Distribution Practices (GDP) using qualified couriers. Reanalysis and repurification can be performed on short notice before shipment or use in our (in-house) studies to help meet project timelines.
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