| Author | Title | Journal | Link |
|---|---|---|---|
| Eberspaecher, U. et al. |
Polo-like kinase 1-inhibitor co-complex structures via the surface-entropy reduction approach and a DARPin-assisted approach |
Acta Crystallogr D Struct Biol, 81, 12, 718-733 (2025) |
https://doi.org/10.1107/S2059798325009325 |
| Alaimo, C. et al. |
Safety and immunogenicity of a Klebsiella pneumoniae tetravalent bioconjugate vaccine (Kleb4V) administered to healthy adults: A first time in human phase I/II randomised and controlled study |
J Infect Dis, jiaf600 (2025) |
https://doi.org/10.1093/infdis/jiaf600 |
| Timmerman, P. et al. |
Beyond contracts: principles for Pharma-CRO collaboration from the European Bioanalysis Forum |
Bioanalysis, 1-5 (2025) |
https://doi.org/10.1080/17576180.2025.2582422 |
| Siegel, F. et al. |
Sevabertinib, a reversible HER2 inhibitor with activity in lung cancer |
Cancer Discov, OF1-OF14 (2025) |
https://doi.org/10.1158/2159-8290.CD-25-0605 |
| Timmerman, P. et al. |
European Bioanalysis Forum recommendation on embracing a context-of-use-driven scientific validation for chromatographic assays in the light of ICH M10. |
Bioanalysis 1-10 (2025) |
https://doi.org/10.1080/17576180.2025.2555774 |
| Herasymenko, O. et al. | CACHE challenge #2: targeting the RNA site of the SARS-CoV-2 helicase Nsp13. |
J Chem Inf Model, 65, 13, 6884-6898 (2025) |
https://doi.org/10.1021/acs.jcim.5c00535 |
| Hughes, R. et al. |
Use of surrogate matrices in bioanalytical preclinical safety testing using immunoassay methods: a recommendation from the European Bioanalysis Forum. |
Bioanalysis, 17, 14, 893-898 (2025) |
https://doi.org/10.1080/17576180.2025.2545136 |
| Timmerman, P. et al. |
Why traditional validation may fall short for artificial intelligence in bioanalysis: a perspective from the European Bioanalysis Forum. |
Bioanalysis, 17, 13, 835-837 (2025) |
https://doi.org/10.1080/17576180.2025.2535219 |
| Strotmann, R. et al. |
Sensitivity of tepotinib to inhibitors or inducers of CYP3A4 and P-Gp: drug interaction studies and physiologically-based pharmacokinetic analysis. |
Clin Transl Sci, 18, 7, e70273 (2025) |
https://doi.org/10.1111/cts.70273 |
| Zehrer, A. et al. |
Enhancing tofacitinib's therapeutic efficacy in murine arthritis with a synbiotic formulation comprising Bacillus megaterium DSM 32963 and an Omega-3 fatty acid lysine salt. |
Front Immunol, 16, 1540878 (2025) |
https://doi.org/10.3389/fimmu.2025.1540878 |
| Steigemann, P. et al. |
Identification of NUV-244 as a PNPLA3 I148M degrading small molecule. |
iScience, 28, 5, 112384 (2025) |
https://doi.org/10-1016/j-isci-2025-112384/ |
| Cowan, KJ. et al. |
Recent discussions and proposals on challenging the 3-tier immunogenicity testing strategies from the European Bioanalysis Forum. |
Bioanalysis, 17, 9, 575-578 (2025) |
https://doi.org/10.1080/17576180.2025.2487377 |
| Ahmad, S. et al. |
Feedback from the 10th European Bioanalysis Forum Young Scientist Symposium and from the Science Café discussions on sustainability in bioanalysis. |
Bioanalysis, 17, 8, 509-514 (2025) |
https://doi.org/10.1080/17576180.2025.2479963 |
| Borrallo-Lopez, L. et al. | Combining the zebrafish embryo developmental toxicity assay (ZEDTA) with hemoglobin staining to accelerate the research of novel antimalarial drugs for pregnant women. | Int J Parasitol Drugs Drug Resist 27, 100582 (2025) | https://doi.org/10.1016/j.ijpddr.2025.100582 |
| von Nussbaum, F. and Testolin, G. |
Opening the door to a new treatment paradigm: the re-emergence of chymase inhibitors. |
J Med Chem, 68, 6, 6100-6103 (2025) |
https://doi.org/10.1021/acs.jmedchem.5c00413 |
| Garaizar, A. et al. |
Perspective on LNP structure and simulation. |
Proc Natl Acad Sci USA, 122, 9, e2423433122 (2025) |
https://doi.org/10.1073/pnas.2423433122 |
| Timmerman, P. et al. | Feedback from a workshop by the European Bioanalysis Forum on assay validation requirements for in vitro assays following the publication of ICH M12 guideline – a plea for context-of-use over ICH M10 standards. | Bioanalysis, 17, 6, 379-382 (2025) | https://doi.org/10.1080/17576180.2025.2468596 |
| Blondeel, E. et al. | The spheroid light microscopy image atlas for morphometrical analysis of three-dimensional cell cultures. | Sci Data, 12, 283 (2025) | https://doi.org/10.1038/s41597-025-04441-x |
| Li, H. Z. et al. | Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2. | Nat Commun, 16, 721 (2025) | https://doi.org/10.1038/s41467-025-55942-7 |
| Author | Title | Journal | Link |
|---|---|---|---|
| Goodwin, L. et al. | The use of surrogate matrices in bioanalytical preclinical safety testing using chromatographic methods: a recommendation from the European Bioanalysis forum. | Bioanalysis 16, 1199–1202 (2024) | https://doi.org/10.1080/17576180.2024.2416360 |
| Arfvidsson, C. et al. | Moving into the cloud: a summary from a European Bioanalysis forum workshop on introducing cloud applications in bioanalytical laboratories. | Bioanalysis 16, 1203–1206 (2024) | https://doi.org/10.1080/17576180.2024.2416357 |
| Schiedel, M. et al. | We are MedChem: The Frontiers in Medicinal Chemistry 2024. | ChemMedChem 19, e202400543 (2024) | https://doi.org/10.1002/cmdc.202400543 |
| Hsiao, W.-K. et al. | Opportunities of topical drug products in a changing dermatological landscape. | Eur J Pharm Sci 203, 106913 (2024) | https://doi.org/10.1016/j.ejps.2024.106913 |
| Hohlbaum, K. et al. | The implementation of tunnel handling in a mouse breeding facility revealed strain-specific behavioural responses. | Lab Anim 58, 552–564 (2024) | https://doi.org/10.1177/00236772231215077 |
| Li, F. et al. | CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein. | J Chem Inf Model 64, 8521–8536 (2024) | https://doi.org/10.1021/acs.jcim.4c01267 |
| Purzner, J. et al. | Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma. | Preprint at https://doi org/10 1101/2024 11 21 624171 (2024) | https://doi.org/10.1101/2024.11.21.624171 |
| Vakalopoulos, A. et al. | Discovery of BAY 2413555, First Selective Positive Allosteric Modulator of the M2 Receptor to Restore Cardiac Autonomic Balance. | J Med Chem 67, 19165–19187 (2024) | https://doi.org/10.1021/acs.jmedchem.4c01590 |
| Garaizar, A. et al. | Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments. | Proc Natl Acad Sci U S A 121, e2404555121 (2024) | https://doi.org/10.1073/pnas.2404555121 |
| Streckfuss‐Bömeke, K. et al. | Physiologists as medical scientists: An early warning from the German academic system. | Physiol Rep 12, e70055 (2024) | https://doi.org/10.14814/phy2.70055 |
| Goodman, J. et al. | Re-thinking the current paradigm for clinical immunogenicity assessment: an update from the discussion in the European Bioanalysis Forum. | Bioanalysis 16, 905–913 (2024) | https://doi.org/10.1080/17576180.2024.2376949 |
| Cowan, K. J. et al. | The European Bioanalysis Forum recommendation on establishing appropriate drug tolerance levels in antidrug antibody assays. | Bioanalysis 16, 915–921 (2024) | https://doi.org/10.1080/17576180.2024.2376950 |
| Schaefer, M. et al. | Surface-mutagenesis strategies to enable structural biology crystallization platforms. | Acta Crystallogr D Struct Biol 80, 661–674 (2024) | https://doi.org/10.1107/s2059798324007939 |
| Rauh, U. et al. | BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models. | Nat Cancer 5, 1479–1493 (2024) | https://doi.org/10.1038/s43018-024-00814-0 |
| Cowan, K. J. et al. | A European Bioanalysis Forum recommendation for requiring a context-of-use statement for successful development and validation of biomarker assays. | Bioanalysis 16, 835–842 (2024) | https://doi.org/10.1080/17576180.2024.2376436 |
| Gelová, Z. et al. | Protein Binder Toolbox for Studies of Solute Carrier Transporters. | J Mol Biol 436, 168665 (2024) | https://doi.org/10.1016/j.jmb.2024.168665 |
| Graham, K. et al. | Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling. | Cell Chem Biol 31, 1247-1263 e16 (2024) | https://doi.org/10.1016/j.chembiol.2024.02.013 |
| Hanckmann, E. et al. | Feedback from the Science Café roundtables at the ninth European Bioanalysis Forum Young Scientist Symposium: optimizing the work–life balance in a bioanalytical laboratory. | Bioanalysis 16, 569–574 (2024) | https://doi.org/10.4155/bio-2024-0054 |
| Karsten, C. B. et al. | Macrophage- and CD4+ T cell-derived SIV differ in glycosylation, infectivity and neutralization sensitivity. | PLoS Pathog 20, e1012190 (2024) | https://doi.org/10.1371/journal.ppat.1012190 |
| Begou, O. et al. | An interview with Bioanalysis : speaking with the 2023 Reid bursary award winners – part 2. | Bioanalysis 16, 221–225 (2024) | https://doi.org/10.4155/bio-2024-0051 |
| Viant, M. R. et al. | Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice. | Arch Toxicol 98, 1111–1123 (2024) | https://doi.org/10.1007/s00204-024-03680-y |
| Zenklusen, I. et al. | Effect of Daridorexant on the Pharmacokinetics of Midazolam, and on the Pharmacokinetics and Pharmacodynamics of Warfarin in Healthy Male Subjects. | Drugs R D 24, 97–108 (2024) | https://doi.org/10.1007/s40268-024-00456-8 |
| Wilhelmi, P. et al. | Molecular signatures of angiogenesis inhibitors: a single-embryo untargeted metabolomics approach in zebrafish. | Arch Toxicol 98, 943–956 (2024) | https://doi.org/10.1007/s00204-023-03655-5 |
| Tug, T. et al. | In vivo alkaline comet assay: Statistical considerations on historical negative and positive control data. | JPT 148, 105583 (2024) | https://doi.org/10.1016/j.yrtph.2024.105583 |
| Timmerman, P. et al. | Recommendations and Feedback from the European Bioanalysis Forum Workshop: 1 Year Into ICH M10 – Keeping Our Finger on the Pulse. | Bioanalysis 16, 259–270 (2024) | https://doi.org/10.4155/bio-2024-0013 |
| Sugawara, T. et al. | Dual targeting of the androgen receptor and PI3K / AKT / mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis. | Mol Oncol 18, 726–742 (2024) | https://doi.org/10.1002/1878-0261.13577 |
| Kamp, H. et al. | Utility of in vivo metabolomics to support read-across for UVCB substances under REACH. | Arch Toxicol 98, 755–768 (2024) | https://doi.org/10.1007/s00204-023-03638-6 |
| Voeltz, D. et al. | A parametric additive hazard model for time-to-event analysis. | BMC Med Res Methodol 24, 48 (2024) | https://doi.org/10.1186/s12874-024-02180-y |
| Falkenstern, L. et al. | A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition | Sci Rep 14, 1739 (2024) | https://doi.org/10.1038/s41598-023-50964-x |
| Aquilanti, E. et al. | Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression. | Neuro-oncol Adv 6, vdae115 (2024) | https://doi.org/10.1093/noajnl/vdae115 |
| Author | Title | Journal | Link |
|---|---|---|---|
| Schneidewind, S. J. et al. | Rumination Detection in Sheep: A Systematic Review of Sensor-Based Approaches. | Animals 13, 3756 (2023) | https://doi.org/10.3390/ani13243756 |
| Becker, A. et al. | Phase I crossover study of DNA‐protein kinase inhibitor peposertib in healthy volunteers: Effect of food and pharmacokinetics of an oral suspension. | Clinical Translational Sci 16, 2628–2639 (2023) | https://doi.org/10.1111/cts.13657 |
| Heller, S. et al. | Pan-PI3K inhibition with copanlisib overcomes Treg- and M2-TAM-mediated immune suppression and promotes anti-tumor immune responses. | Clin Exp Med 23, 5445–5461 (2023) | https://doi.org/10.1007/s10238-023-01227-6 |
| Gehringer, M. et al. | Back in Person: Frontiers in Medicinal Chemistry 2023. | ChemMedChem 18, e202300344 (2023) | https://doi.org/10.1002/cmdc.202300344 |
| Raturi, S. et al. | High-Throughput Expression and Purification of Human Solute Carriers for Structural and Biochemical Studies. | JoVE 65878 (2023) | https://doi.org/10.3791/65878 |
| Neves, M. et al. | Automatic classification of experimental models in biomedical literature to support searching for alternative methods to animal experiments. | J Biomed Semant 14, 13 (2023) | https://doi.org/10.1186/s13326-023-00292-w |
| Langer, G. et al. | Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor. | Mol Pharm 104, 105–114 (2023) | https://doi.org/10.1124/molpharm.122.000662 |
| Billié, S. et al. | Identification of unknown impurities J, RRT 2.2, 2.4, 2.6 and 3.4 in tetralysal® capsules. | Eur J Pharm Sci 188, 106519 (2023) | https://doi.org/10.1016/j.ejps.2023.106519 |
| Yalkinoglu, Ö. et al. | Assessment of the potential of the MET inhibitor tepotinib to affect the pharmacokinetics of CYP3A4 and P-gp substrates. | Invest New Drugs 41, 596–605 (2023) | https://doi.org/10.1007/s10637-023-01378-z |
| Borek, B. et al. | Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy. | Mol Cancer Ther 22, 807–817 (2023) | https://doi.org/10.1158/1535-7163.mct-22-0721 |
| Ali, A. et al. | European Medicinal Chemistry Leaders in Industry (EMCL) – On the Status and Future of Medicinal Chemistry Research in Europe** | ChemMedChem 18, e202300127 (2023) | https://doi.org/10.1002/cmdc.202300127 |
| Vakalopoulos, A. et al. | New Generation of sGC Stimulators: Discovery of Imidazo[1,2- a ]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension. | J Med Chem 66, 7280–7303 (2023) | https://doi.org/10.1021/acs.jmedchem.2c02082 |
| Duman, C. et al. | Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion. | Cell Death Dis 14, 296 (2023) | https://doi.org/10.1038/s41419-023-05813-0 |
| Grünewald, S. et al. | Effects of regorafenib on the mononuclear/phagocyte system and how these contribute to the inhibition of colorectal tumors in mice. | Eur J Med Res 28, 147 (2023) | https://doi.org/10.1186/s40001-023-01099-2 |
| Schnerwitzki, D. et al. | Adapting the pantograph limb: Differential robustness of fore- and hindlimb kinematics against genetically induced perturbation in the neural control networks and its evolutionary implications. | Zoology 157, 126076 (2023) | https://doi.org/10.1016/j.zool.2023.126076 |
| Göricke, F. et al. | Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. | Med Chem 66, 3431–3447 (2023) | https://doi.org/10.1021/acs.jmedchem.2c01933 |
| Zablowsky, N. et al. | High Throughput FISH Screening Identifies Small Molecules That Modulate Oncogenic lncRNA MALAT1 via GSK3B and hnRNPs. | ncRNA 9, 2 (2023) | https://doi.org/10.3390/ncrna9010002 |
| Orsi, D. L. et al. | Discovery and characterization of orally bioavailable 4-chloro-6-fluoroisophthalamides as covalent PPARG inverse-agonists. | Bioorg Med Chem 78, 117130 (2023) | https://doi.org/10.1016/j.bmc.2022.117130 |
| Ackloo, S. et al. | Target 2035 – an update on private sector contributions. | RSC Med Chem 14, 1002–1011 (2023) | https://doi.org/10.1039/d2md00441k |
| Author | Title | Journal | Link |
|---|---|---|---|
| Karwelat, D. et al. | A rodent thyroid-liver chip to capture thyroid toxicity on organ functional level | ALTEX 40, 1 (2022) | https://doi.org/10.14573/altex.2108262 |
| Heughebaert, L. et al. | Feedback from the 8th European Bioanalysis Forum Young Scientist Symposium | Bioanalysis 14, 1471–1477 (2022) | https://doi.org/10.4155/bio-2022-0232 |
| Timmerman, P. et al. | Conference report from the European Bioanalysis Forum workshop: toward harmonised implementation of the ICH M10 guideline | Bioanalysis 14, 22, 1407–1411 (2022) | https://doi.org/10.4155/bio-2022-0229 |
| Bertani, V. et al. | Artificial intelligence in toxicological pathology: quantitative evaluation of compound-induced follicular cell hypertrophy in rat thyroid gland using deep learning models | Toxicol Pathol 50, 1, 23–34 (2021) | https://doi.org/10.1177/01926233211052010 |
| Novak, B. et al. | Clinical pharmacokinetics and safety of a 10% aminolevulinic acid hydrochloride nanoemulsion gel (BF‐200 ALA) in photodynamic therapy of patients extensively affected with actinic keratosis: results of 2 maximal usage pharmacokinetic trials | Clinical Pharm in Drug Dev 11, 4, 535–550 (2022) | https://doi.org/10.1002/cpdd.1023 |
| Müller, S.et al. | Target 2035 – update on the quest for a probe for every protein | RSC Med Chem 13, 13–21 (2022) | https://doi.org/10.1039/D1MD00228G |
| Hillig, R. C. & Bader, B. | Targeting RAS oncogenesis with SOS1 inhibitors | Advances in Cancer Research vol. 153 169–203 (Elsevier, 2022) | https://doi.org/10.1016/bs.acr.2021.07.001 |
| Henß, T. et al. | Optogenetic tools for manipulation of cyclic nucleotides functionally coupled to cyclic nucleotide‐gated channels | British J Pharmacology 179, 11, 2519–2537 (2022) | https://doi.org/10.1111/bph.15445 |
| Schüssele, L. M. et al. | Establishment of a novel method to assess MEK1/2 inhibition in PBMCs for clinical drug development | Front Cell Dev Biol 10, 1063692 (2022) | https://doi.org/10.3389/fcell.2022.1063692 |
| Billié, S. et al. | Completion of the impurity profile of lymecycline: formal identification of impurities E and F | Journal of Pharmaceutical and Biomedical Analysis 220, 114993 (2022) | https://doi.org/10.1016/j.jpba.2022.114993 |
| Orsi, D. L. et al. | Discovery and structure-based design of potent covalent PPARγ inverse-agonists BAY-4931 and BAY-0069 | J Med Chem 65, 21, 14843–14863 (2022) | https://doi.org/10.1021/acs.jmedchem.2c01379 |
| Diamanti, E. et al. | Frontiers in medicinal chemistry 2022 goes virtual | ChemMedChem 17, 21, e202200419 (2022) | https://doi.org/10.1002/cmdc.202200419 |
| Boiteau, J..G. et al. | Complete [1H], [13C] and [15N] assignments of the minor isomer of codeine N‐oxide | Magnetic Reson in Chemistry 60, 12, 1185–1188 (2022) | https://doi.org/10.1002/mrc.5302 |
| Cowan, K. J. et al. | Biomarker context-of-use: how organisational design can impact the implementation of the appropriate biomarker assay strategy | Bioanalysis 14, 13, 911–917 (2022) | https://doi.org/10.4155/bio-2022-0143 |
| Pla, L. et al. | Protocols for the evaluation of neurodevelopmental alterations in rabbit models in vitro and in vivo | Front Toxicol 4, 918520 (2022) | https://doi.org/10.3389/ftox.2022.918520 |
| Regan, J. L. et al. | Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis | iScience 25, 7, 104498 (2022) | https://doi.org/10.1016/j.isci.2022.104498 |
| Hohlbaum, K. et al. | Effects of separated pair housing of female C57BL/6JRj mice on well-being | Sci Rep 12, 8819 (2022) | https://doi.org/10.1038/s41598-022-12846-6 |
| Alborzinia, H. et al. | MYCN mediates cysteine addiction and sensitises neuroblastoma to ferroptosis | Nat Cancer 3, 471–485 (2022) | https://doi.org/10.1038/s43018-022-00355-4 |
| Chume, F. C. et al. | Glycated albumin in diabetes mellitus: a meta-analysis of diagnostic test accuracy | Clinical Chemistry and Laboratory Medicine (CCLM) 60, 7, 961–974 (2022) | https://doi.org/10.1515/cclm-2022-0105 |
| Del Amo, E. M. et al. | Ocular metabolism and distribution of drugs in the rabbit eye: quantitative assessment after intracameral and intravitreal administrations | International Journal of Pharmaceutics 613, 121361 (2022) | https://doi.org/10.1016/j.ijpharm.2021.121361 |
| Speck, D. et al. | Expression and characterisation of relaxin family peptide receptor 1 variants | Front Pharmacol 12, 826112 (2022) | https://doi.org/10.3389/fphar.2021.826112 |
| Lerchen, H.-G. et al. | A small molecule–drug conjugate (SMDC) consisting of a modified camptothecin payload linked to an αVß3 binder for the treatment of multiple cancer types | Cancers 14, 2, 391 (2022) | https://doi.org/10.3390/cancers14020391 |
| Author | Title | Journal | Link |
|---|---|---|---|
| Bannik, K. et al. | DNA repair inhibitors sensitise cells differently to high and low LET radiation | Sci Rep 11, 23257 (2021) | https://doi.org/10.1038/s41598-021-02719-9 |
| Peirsman, A. et al. | MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity | Nat Methods 18, 1294–1303 (2021) | https://doi.org/10.1038/s41592-021-01291-4 |
| Wortmann, L. et al. | Discovery and characterisation of the potent and highly selective 1,7-naphthyridine-based inhibitors BAY-091 and BAY-297 of the kinase PIP4K2A | J Med Chem 64, 21, 15883–15911 (2021) | https://doi.org/10.1021/acs.jmedchem.1c01245 |
| Klaus, M. et al. | Ultrahigh‐throughput detection of enzymatic alcohol dehydrogenase activity in microfluidic droplets with a direct fluorogenic assay | ChemBioChem 22, 23, 3292–3299 (2021) | https://doi.org/10.1002/cbic.202100322 |
| Davenport, A. J. et al. | Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers | Sci Rep 11, 19877 (2021) | https://doi.org/10.1038/s41598-021-99177-0 |
| Timmerman, P. et al. | Recommendations and discussion points on immunogenicity, biomarkers, automation/technology and protein–MS From the 2021 European Bioanalysis Forum focus workshops | Bioanalysis 13, 19, 1459–1465 (2021) | https://doi.org/10.4155/bio-2021-0200 |
| Doleschel, D. et al. | Regorafenib enhances anti-PD1 immunotherapy efficacy in murine colorectal cancers and their combination prevents tumour regrowth | J Exp Clin Cancer Res 40, 288 (2021) | https://doi.org/10.1186/s13046-021-02043-0 |
| Munday, C. et al. | Feedback from the Science Café at the 7th European Bioanalysis Forum Young Scientist Symposium | Bioanalysis 13, 24, 1793-1798 (2021) | https://doi.org/10.4155/bio-2021-0187 |
| Gradl, S. et al. | Discovery of the SMYD3 inhibitor BAY-6035 using thermal shift assay (TSA)-based high-throughput screening | SLAS Discov 26, 8, 947–960 (2021) | https://doi.org/10.1177/24725552211019409 |
| Berger, M. et al. | BAY-8400: a novel potent and selective DNA-PK inhibitor which shows synergistic efficacy in combination with targeted alpha therapies | J Med Chem 64, 17, 12723–12737 (2021) | https://doi.org/10.1021/acs.jmedchem.1c00762 |
| Port, A. et al. | Phase 1 study in healthy participants of the safety, pharmacokinetics and pharmacodynamics of Enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8 | Pharmacology Res & Perspec 9, 5, e00842 (2021) | https://doi.org/10.1002/prp2.842 |
| Dieter, S. M. et al. | Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer | Cell Reports 36, 3, 109394 (2021) | https://doi.org/10.1016/j.celrep.2021.109394 |
| Garvie, C. W. et al. | Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase | Nat Commun 12, 4375 (2021) | https://doi.org/10.1038/s41467-021-24495-w |
| Witte, F. et al. | A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion | Genome Biol 22, 191 (2021) | https://doi.org/10.1186/s13059-021-02397-w |
| Krause, B. C. et al. | Combinatory effects of cerium dioxide nanoparticles and acetaminophen on the liver — a case study of low-dose interactions in human HuH-7 cells | IJMS 22, 13, 6866 (2021) | https://doi.org/10.3390/ijms22136866 |
| Regan, J. L. et al. | RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence | iScience 24, 6, 102618 (2021) | https://doi.org/10.1016/j.isci.2021.102618 |
| Kammertoens, T. et al. | Breeding and maintenance of immunodeficient mouse lines under SPF conditions — a call for individualised severity analyses and approval procedures | Animals 11, 6, 1789 (2021) | https://doi.org/10.3390/ani11061789 |
| Lücking, U. et al. | Changing for the better: discovery of the highly potent and selective CDK9 inhibitor VIP152 suitable for once weekly intravenous dosing for the treatment of cancer | J Med Chem 64, 15, 11651–11674 (2021) | https://doi.org/10.1021/acs.jmedchem.1c01000 |
| Taavitsainen, P. et al. | Metabolism and mass balance of the novel nonsteroidal androgen receptor inhibitor darolutamide in humans | Drug Metab Dispos 49, 6, 420–433 (2021) | https://doi.org/10.1124/dmd.120.000309 |
| Suominen, M. I. et al. | Additive benefits of radium-223 dichloride and Bortezomib combination in a systemic multiple myeloma mouse model | IJMS 22, 11, 5570 (2021) | https://doi.org/10.3390/ijms22115570 |
| Hahn, M. G. et al. | Discovery of the soluble guanylate cyclase activator Runcaciguat (BAY 1101042) | J Med Chem 64, 9, 5323–5344 (2021) | https://doi.org/10.1021/acs.jmedchem.0c02154 |
| Delahaye, L. et al. | Feedback from the sixth European Bioanalysis Forum Young Scientist Symposium | Bioanalysis 13, 9, 669–674 (2021) | https://doi.org/10.4155/bio-2021-0051 |
| Ede, S. et al. | Improved diazo-transfer reaction for DNA-encoded chemistry and its potential application for macrocyclic DEL-libraries | Molecules 26, 6, 1790 (2021) | https://doi.org/10.3390/molecules26061790 |
| Liu, D. et al. | Nickel‐catalysed N‐arylation of NH‐sulfoximines with aryl halides via paired electrolysis | Angew Chem Int Ed 60, 17, 9444–9449 (2021) | https://doi.org/10.1002/anie.202016310 |
| Calogero, S. et al. | Feedback from the Science Café from the sixth European Bioanalysis Forum Young Scientist Symposium | Bioanalysis 13, 3, 129–133 (2021) | https://doi.org/10.4155/bio-2021-0017 |
| Sutherland, M. et al. | Rational design and synthesis of selective PRMT4 inhibitors: a new chemotype for development of cancer therapeutics | ChemMedChem 16, 7, 1116–1125 (2021) | https://doi.org/10.1002/cmdc.202100018 |
| Moosmayer, D. et al. | Crystal structures of the selenoprotein glutathione peroxidase 4 in its apo form and in complex with the covalently bound inhibitor ML162 | Acta Crystallogr D Struct Biol 77, 2, 237–248 (2021) | https://doi.org/10.1107/S2059798320016125 |
| Lemos, C. et al. | The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models | Cell Oncol 44, 581–594 (2021) | https://doi.org/10.1007/s13402-020-00584-8 |
| Pischon, H. et al. | Artificial intelligence in toxicologic pathology: quantitative evaluation of compound-induced hepatocellular hypertrophy in rats | Toxicol Pathol 49, 4, 928–937 (2021) | https://doi.org/10.1177/0192623320983244 |
| Lissy, M. et al. | Thorough QT/QTc study evaluating the effect of macimorelin on cardiac safety parameters in healthy participants | Clinical Pharm in Drug Dev 10, 5, 494–501 (2021) | https://doi.org/10.1002/cpdd.872 |
| Atilaw, Y. et al. | Solution conformations shed light on PROTAC cell permeability | ACS Med Chem Lett 12, 1, 107–114 (2021) | https://doi.org/10.1021/acsmedchemlett.0c00556 |
| Author | Title | Journal | Link |
|---|---|---|---|
| Hillisch, A. et al. | Design, synthesis and pharmacological characterisation of a neutral, non-prodrug thrombin inhibitor with good oral pharmacokinetics | J Med Chem 63, 21, 12574–12594 (2020) | https://doi.org/10.1021/acs.jmedchem.0c01035 |
| Goodman, J. et al. | Update to the European Bioanalysis Forum recommendation on biomarkers assays: bringing context of use into practice | Bioanalysis 12, 1427–1437 (2020) | https://doi.org/10.4155/bio-2020-0243 |
| Agueusop, I. et al. | Short-term variability of the human serum metabolome depending on nutritional and metabolic health status | Sci Rep 10, 16310 (2020) | https://doi.org/10.1038/s41598-020-72914-7 |
| Lemos, C. et al. | Identification of small molecules that modulate mutant p53 condensation | iScience 23, 11, 101517 (2020) | https://doi.org/10.1016/j.isci.2020.101517 |
| Panknin, O. et al. | Discovery and characterisation of BAY 1214784, an orally available spiroindoline derivative acting as a potent and selective antagonist of the human gonadotropin-releasing hormone receptor as proven in a first-in-human study in postmenopausal women | J Med Chem 63, 20, 11854–11881 (2020) | https://doi.org/10.1021/acs.jmedchem.0c01076 |
| Werbeck, N. D. et al. | A distal regulatory region of a class I human histone deacetylase | Nat Commun 11, 3841 (2020) | https://doi.org/10.1038/s41467-020-17610-w |
| Zhao, X.-Y. et al. | Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia | Nat Commun 11, 2992 (2020) | https://doi.org/10.1038/s41467-020-16720-9 |
| Lücking, U. et al. | Damage incorporated: discovery of the potent, highly selective, orally available ATR inhibitor BAY 1895344 with favorable pharmacokinetic properties and promising efficacy in monotherapy and in combination treatments in preclinical tumour models | J Med Chem 63, 13, 7293–7325 (2020) | https://doi.org/10.1021/acs.jmedchem.0c00369 |
| Schulze, V. K. et al. | Treating cancer by spindle assembly checkpoint abrogation: discovery of two clinical candidates, BAY 1161909 and BAY 1217389, targeting MPS1 kinase | J Med Chem 63, 15, 8025–8042 (2020) | https://doi.org/10.1021/acs.jmedchem.9b02035 |
| Timmerman, P. et al. | European Bioanalysis Forum feedback on draft ICH M10 guideline on bioanalytical method validation during the step 2b public consultation period | Bioanalysis 12, 1–11 (2020) | https://doi.org/10.4155/bio-2020-0065 |
| Klaus, B. et al. | Safety, tolerability, pharmacokinetics and pharmacodynamics of Macimorelin in healthy adults: results of a single-dose, randomised controlled study | Growth Hormone & IGF Research 52, 101321 (2020) | https://doi.org/10.1016/j.ghir.2020.101321 |
| Mortier, J. et al. | Computationally empowered workflow identifies novel covalent allosteric binders for KRASG12C | ChemMedChem 15, 10, 827–832 (2020) | https://doi.org/10.1002/cmdc.201900727 |
| Eaton, J. K. et al. | Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles | Nat Chem Biol 16, 497–506 (2020) | https://doi.org/10.1038/s41589-020-0501-5 |
| Wu, X. et al. | Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and Schlafen family member 12 | J Biol Chem 295, 11, 3431–3446 (2020) | https://doi.org/10.1074/jbc.RA119.011191 |
| Taavitsainen, P. et al. | Absorption, distribution, metabolism and excretion of darolutamide (a novel non-steroidal androgen receptor antagonist) in rats | Xenobiotica 50, 8, 967–979 (2020) | https://doi.org/10.1080/00498254.2020.1723038 |
| Brzezinka, K. et al. | Characterisation of the menin-MLL interaction as therapeutic cancer target | Cancers (Basel) 12, 1, 201 (2020) | https://doi.org/10.3390/cancers12010201 |
| Parker, V. E. R. et al. | Efficacy, safety and mechanistic insights of Cotadutide, a dual receptor glucagon-like peptide-1 and glucagon agonist | The Journal of Clinical Endocrinology & Metabolism 105, 803–820 (2020) | https://doi.org/10.1210/clinem/dgz047 |
| Lefranc, J. et al. | Discovery of BAY-985, a highly selective TBK1/IKKε inhibitor | J Med Chem 63, 601–612 (2020) | https://doi.org/10.1021/acs.jmedchem.9b01460 |
| Wengner, A. M. et al. | The novel ATR inhibitor BAY 1895344 is efficacious as monotherapy and combined with DNA damage-inducing or repair-compromising therapies in preclinical cancer models | Mol Cancer Ther 19, 1, 26–38 (2020) | https://doi.org/10.1158/1535-7163.MCT-19-0019 |
| Author | Title | Journal | Link |
|---|---|---|---|
| Werner, S. et al. | Discovery and characterisation of the potent and selective P2X4 inhibitor N-[4-(3-chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and structure-guided amelioration of its CYP3A4 induction profile | J Med Chem 62, 24, 11194–11217 (2019) | https://doi.org/10.1021/acs.jmedchem.9b01304 |
| Pihl, S. et al. | EBF recommendation on practical management of critical reagents for antidrug antibody ligand-binding assays | Bioanalysis 11, 19, 1787–1798 (2019) | https://doi.org/10.4155/bio-2019-0248 |
| Lewis, T. A. et al. | Optimisation of PDE3A modulators for SLFN12-dependent cancer cell killing | ACS Med Chem Lett 10, 11, 1537–1542 (2019) | https://doi.org/10.1021/acsmedchemlett.9b00360 |
| Zurth, C. et al. | Drug-drug interaction potential of darolutamide: in vitro and clinical studies | Eur J Drug Metab Pharmacokinet 44, 747–759 (2019) | https://doi.org/10.1007/s13318-019-00577-5 |
| Shore, N. et al. | Evaluation of clinically relevant drug-drug interactions and population pharmacokinetics of darolutamide in patients with nonmetastatic castration-resistant prostate cancer: results of pre-specified and post hoc analyses of the phase III ARAMIS trial | Target Oncol 14, 527–539 (2019) | https://doi.org/10.1007/s11523-019-00674-0 |
| Protti, M. et al. | Feedback from the fifth European Bioanalysis Forum Young Scientist Symposium | Bioanalysis 11, 16, 1453–1458 (2019) | https://doi.org/10.4155/bio-2019-0206 |
| Brzezinka, K. et al. | Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia | J Hematol Oncol 12, 66 (2019) | https://doi.org/10.1186/s13045-019-0749-y |
| Renders, L. et al. | First-in-human phase I studies of PRS-080#22, a hepcidin antagonist, in healthy volunteers and patients with chronic kidney disease undergoing hemodialysis | PLoS ONE 14, e0212023 (2019) | https://doi.org/10.1371/journal.pone.0212023 |
| Grünewald, S. et al. | Rogaratinib: a potent and selective pan-FGFR inhibitor with broad antitumour activity in FGFR-overexpressing preclinical cancer models | Int J Cancer 145, 5, 1346–1357 (2019) | https://doi.org/10.1002/ijc.32224 |
| Siemeister, G. et al. | Inhibition of BUB1 kinase by BAY 1816032 sensitises tumour cells toward taxanes, ATR and PARP inhibitors in vitro and in vivo | Clin Cancer Res 25, 4, 1404–1414 (2019) | https://doi.org/10.1158/1078-0432.CCR-18-0628 |
| Zahner, C. et al. | No clinically relevant interactions of St. John's wort extract Ze 117 low in hyperforin with cytochrome P450 enzymes and P‐glycoprotein | Clin Pharma and Therapeutics 106, 2, 432–440 (2019) | https://doi.org/10.1002/cpt.1392 |
| Vriens, K. et al. | Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity | Nature 566, 403–406 (2019) | https://doi.org/10.1038/s41586-019-0904-1 |
| Hillig, R. C. et al. | Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction | Proc Natl Acad Sci U S A 116, 7, 2551–2560 (2019) | https://doi.org/10.1073/pnas.1812963116 |
| Wilson, A. et al. | European Bioanalysis Forum recommendation on the best practices to demonstrate processed sample stability | Bioanalysis 11, 1, 7–11 (2019) | https://doi.org/10.4155/bio-2018-0271 |
| Nguyen, D. et al. | Discovery and characterisation of the potent and highly selective (piperidin-4-yl)pyrido[3,2- d]pyrimidine based in vitro probe BAY-885 for the kinase ERK5 | J Med Chem 62, 2,928–940 (2019) | https://doi.org/10.1021/acs.jmedchem.8b01606 |
| Author | Title | Journal | Link |
|---|---|---|---|
| Kall, M. A. et al. | Incurred sample reproducibility: 10 years of experiences: views and recommendations from the European Bioanalysis Forum | Bioanalysis 10, 21, 1723–1732 (2018) | https://doi.org/10.4155/bio-2018-0194 |
| Quanz, M. et al. | Preclinical efficacy of the novel monocarboxylate transporter 1 inhibitor BAY-8002 and associated markers of resistance | Mol Cancer Ther 17, 11, 2285–2296 (2018) | https://doi.org/10.1158/1535-7163.MCT-17-1253 |
| Timmerman, P. et al. | Toward decision-based acceptance criteria for bioanalytical method validation: a proposal for discussion from the European Bioanalysis Forum | Bioanalysis 10, 16, 1255–1259 (2018) | https://doi.org/10.4155/bio-2018-0131 |
| Klutzny, S. et al. | PDE5 inhibition eliminates cancer stem cells via induction of PKA signalling | Cell Death Dis 9, 192 (2018) | https://doi.org/10.1038/s41419-017-0202-5 |
| Goodman, J. et al. | Feedback from the European Bioanalysis Forum: focus workshop on current analysis of immunogenicity: best practices and regulatory hurdles | Bioanalysis 10, 8, 197–204 (2018) | https://doi.org/10.4155/bio-2017-4971 |
| Schultze-Mosgau, M.-H. et al. | Characterisation of the pharmacokinetics of Vilaprisan: Bioavailability, excretion, biotransformation and drug-drug interaction potential | Clin Pharmacokinet 57, 1001–1015 (2018) | https://doi.org/10.1007/s40262-017-0607-4 |
| Author | Title | Journal | Link |
|---|---|---|---|
| Lücking, U. et al. | Identification of Atuveciclib (BAY 1143572), the first highly selective, clinical PTEFb/CDK9 inhibitor for the treatment of cancer |
ChemMedChem 12, 21, 1776–1793 (2017) | https://doi.org/10.1002/cmdc.201700447 |
| Ellermann, M. et al. | Novel class of potent and cellularly active inhibitors devalidates MTH1 as broad-spectrum cancer target |
ACS Chem Biol 12, 8, 1986–1992 (2017) |
https://doi.org/10.1021/acschembio.7b00370 |
| Willuda, J. et al. | Preclinical antitumour efficacy of BAY 1129980 - a novel Auristatin-based anti-C4.4A (LYPD3) antibody-drug conjugate for the treatment of non-small cell lung cancer |
Mol Cancer Ther 16, 5, 893–904 (2017) |
https://doi.org/10.1158/1535-7163.MCT-16-0474 |
| Undre, N. & Dickinson, J. | Relative bioavailability of single doses of prolonged-release tacrolimus administered as a suspension, orally or via a nasogastric tube, compared with intact capsules: a phase 1 study in healthy participants |
BMJ Open 7, 4, e012252 (2017) |
https://doi.org/10.1136/bmjopen-2016-012252 |
| Santag, S. et al. | BAY 1143269, a novel MNK1 inhibitor, targets oncogenic protein expression and shows potent anti-tumour activity |
Cancer Lett 390, 21–29 (2017) |
https://doi.org/10.1016/j.canlet.2016.12.029 |
| Klutzny, S. et al. | Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumour cell death |
Cell Death Dis 8, e2709 (2017) |
https://doi.org/10.1038/cddis.2017.130 |
| Basit, F. et al. | Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells |
Cell Death Dis 8, e2716 (2017) |
https://doi.org/10.1038/cddis.2017.133 |
| Ericzon, B. et al. | Pharmacokinetics of prolonged‐release tacrolimus versus immediate‐release tacrolimus in de novo liver transplantation: a randomised phase III substudy |
Clinical Transplantation 31, 6, e12958 (2017) |
https://doi.org/10.1111/ctr.12958 |
| Pusch, S. et al. | Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo |
Acta Neuropathol 133, 629–644 (2017) |
https://doi.org/10.1007/s00401-017-1677-y |
| Politz, O. et al. | BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signalling-dependent tumour growth in mouse models |
Int J Cancer 140, 2, 449–459 (2017) |
https://doi.org/10.1002/ijc.30457 |
| Author | Title | Journal | Link |
|---|---|---|---|
| Sommer, A. et al. |
Preclinical efficacy of the Auristatin-based antibody-drug conjugate BAY 1187982 for the treatment of FGFR2-positive solid tumors | Cancer Res 76, 21, 6331–6339 (2016 | https://doi.org/10.1158/0008-5472.CAN-16-0180 |
| Schütt, B. et al. | Pharmacodynamics and safety of the novel selective progesterone receptor modulator Vilaprisan: a double-blind, randomised, placebo-controlled phase 1 trial in healthy women | Hum Reprod 31, 8, 1703–1712 (2016) | https://doi.org/10.1093/humrep/dew140 |
| Eggert, E. et al. | Discovery and characterisation of a highly potent and selective aminopyrazoline-based in vivo probe (BAY-598) for the protein lysine methyltransferase SMYD2 | J Med Chem 59, 10, 4578–4600 (2016) | https://doi.org/10.1021/acs.jmedchem.5b01890 |
| Kapoor, K. et al. | Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides |
Proc Natl Acad Sci U S A 113, 17, 4711–4716 (2016) | https://doi.org/10.1073/pnas.1603735113 |
| Wengner, A. M. et al. | Novel Mps1 kinase inhibitors with potent antitumour activity | Mol Cancer Ther 15, 4, 583–592 (2016) | https://doi.org/10.1158/1535-7163.MCT-15-0500 |
| Reynoird, N. et al. | Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer |
Genes Dev 30, 7, 772–785 (2016) | https://doi.org/10.1101/gad.275529.115 |
| Baron, A. P. et al. | Probing the catalytic functions of BUB1 kinase using the small molecule inhibitors BAY-320 and BAY-524 |
Elife 5, e12187 (2016) | https://doi.org/10.7554/eLife.12187 |
| Hernando, H. et al. | EZH2 inhibition blocks multiple myeloma cell growth through upregulation of epithelial tumour suppressor genes |
Mol Cancer Ther 15, 2, 287–298 (2016) | https://doi.org/10.1158/1535-7163.MCT-15-0486 |
| Ferreira de Freitas, R. et al. | Discovery of a potent class I protein arginine methyltransferase fragment inhibitor | J Med Chem 59, 3, 1176–1183 (2016) | https://doi.org/10.1021/acs.jmedchem.5b01772 |
| Sugawara, T. et al. | BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients | Oncotarget 7, 6015–6028 (2016) | https://doi.org/10.18632/oncotarget.6864 |
| Hartung, I. V. et al. | Optimisation of allosteric MEK inhibitors. Part 2: taming the sulfamide group balances compound distribution properties |
Bioorg Med Chem Lett 26, 1, 186–193 (2016) | https://doi.org/10.1016/j.bmcl.2015.11.004 |
| Author | Title | Journal | Link |
|---|---|---|---|
| Luense, S. et al. |
Quantification of histone H3 Lys27 trimethylation (H3K27me3) by high-throughput microscopy enables cellular large-scale screening for small-molecule EZH2 inhibitors |
J Biomol Screen 20, 2, 190–201 (2015) |
https://doi.org/10.1177/1087057114559668 |
| Meier, J. C. et al. |
Knockdown of platinum-induced growth differentiation factor 15 abrogates p27-mediated tumour growth delay in the chemoresistant ovarian cancer model A2780cis |
Cancer Med 4, 2, 253–267 (2015) |
https://doi.org/10.1002/cam4.354 |
| Schulze, J. et al. | Cell-based protein stabilisation assays for the detection of interactions between small-molecule inhibitors and BRD4 |
J Biomol Screen 20, 2, 180–189 (2015) |
https://doi.org/10.1177/1087057114552398 |
| von Nussbaum, F. and Süssmuth, R. D. |
Multiple attack on bacteria by the new antibiotic teixobactin |
Angew Chem Int Ed Engl 54, 23, 6684–6686 (2015) |
https://doi.org/10.1002/anie.201501440 |
| von Nussbaum, F. et al. |
Freezing the bioactive conformation to boost potency: the identification of BAY 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseases |
Chem Med Chem 10, 7, 1163–1173 (2015) |
https://doi.org/10.1002/cmdc.201500131 |
| Gentili, C. et al. |
Chromosome missegregation associated with RUVBL1 deficiency |
PLoS One 10, 7, e0133576 (2015) |
https://doi.org/10.1371/journal.pone.0133576 |
| Nakamaru, Y. et al. |
Investigation of potential pharmacokinetic interactions between Teneligliptin and Metformin in steady-state conditions in healthy adults |
Clinical Therapeutics 37, 9, 2007–2018 (2015) |
https://doi.org/10.1016/j.clinthera.2015.06.012 |
| von Nussbaum, F. and Li, V. M.-J. | Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: into clinical testing with pre-adaptive pharmacophores |
Bioorg Med Chem Lett 25, 20, 4370–4381 (2015) |
https://doi.org/10.1016/j.bmcl.2015.08.049 |
| Wenzel, C. et al. |
A novel 3D high-content assay identifies compounds that prevent fibroblast invasion into tissue surrogates |
Exp Cell Res 339, 1, 35–43 (2015) |
https://doi.org/10.1016/j.yexcr.2015.10.003 |
| Hartung, I. V. et al. |
Modular assembly of allosteric MEK inhibitor structural elements unravels potency and feedback-modulation handles |
Chem Med Chem 10, 12, 2004–2013 (2015) |
https://doi.org/10.1002/cmdc.201500442 |
Contact Us
Search