Oncology models

Our oncology in vivo services

Our diverse tumour-bearing animal models enable in-depth characterisation of novel drug candidates, addressing critical questions for further development. With hands-on experience in over 200 preclinical oncology models in mice and rats, our scientists are well-equipped to support you. We design and conduct in vivo pharmacology studies tailored to your specific needs, helping ensure the best outcomes for your drug development projects.

Comprehensive cancer models and advanced imaging for drug development

We offer a range of xenograft and syngeneic models for multiple cancer indications, including solid and hematologic tumours, metastasis, colonisation and immuno-oncology models. Our services encompass various study types such as tolerability, pharmacokinetic and pharmacodynamic analyses, anti-tumour efficacy, imaging and radiation. With experience in small molecules and biologics, we provide analysis options including tumour growth kinetics, biomarker analysis and immune cell profiling. Our small animal facility is equipped with advanced imaging capabilities, including bioluminescence, µCT and ultrasound.

Xenograft and syngeneic models for multiple indications

• Subcutaneous and orthotopic
• Solid and hematologic tumour models
• Metastasis and colonisation models
• Immuno-oncology models
• Model establishment
• In vivo model database with response data.

Study types

• Tolerability
• Pharmacokinetic (PK) and pharmacodynamic (PD)
• Anti-tumour efficacy
• Imaging (bioluminescence, µCT)
• Radiation
• Experience with small molecules and biologics.

Analysis options

• Tumour growth kinetics, tumour weights, humane end-point survival
• Re-growth assessment after treatment stop
• PK/PD (biomarker) ex vivo analysis in organs/tissues and tumours
• Ex vivo analysis of bodily fluids (cytokine profiling, multicolour flow cytometry)
• Gene expression profiling
• Profiling of immune status/immune cell profiling by IHC/RNAscope/multicolour flow cytometry.

 We have a knowledgebase of over 200 oncology preclinical CDX models. A list of available models follows (further models may be available upon request).