Skip to main content

Technology platforms

Empowering drug discovery with advanced technology  

Our expertise in disease and target biology is enhanced by state-of-the-art technology platforms, supporting your drug discovery projects across all indications and modalities. We monitor functional readouts, such as cellular phenotypic drug responses, using high-content assays, Meso Scale Discovery, precision protein analysis and multiparametric flow cytometry (FACS). Our next-generation sequencing and single-cell sequencing services provide mode-of-action analysis at excellent resolutions. 

Immunostaining of subcellular features

Multicolor flow cytometry 

Our multicolour flow cytometry services are essential for identifying new drug targets, screening potential drug candidates and analysing drug effects on specific cell populations. We offer comprehensive panels for immunoprofiling with established and validated assays for all major mouse and human immune cell populations. Our advanced flow cytometry devices include Cytek Aurora (full-spectrum technology), BD Canto II, Sartorius Intellicyt iQueScreener PLUS and Sony MA900 cell sorter. Selected applications include: 

  • Immuno-oncology 
  • Biomarker identification and validation 
  • Target identification and validation 
  • Compound mode-of-action and efficacy 
  • Immunoprofiling 
  • Immunophenotyping of all immune cell populations, including T, B, and NK cells, regulatory T cells, naïve and activated T cells, memory and effector T cells, naïve and memory B cells, non-classical and classical monocytes, macrophages and dendritic cells, with room for additional markers and dyes for tailored scientific investigations 
  • Antibody screening 
  • Cell sorting for subsequent single-cell sequencing. 
 

Precision protein analysis for mode-of-action insights 

Our protein detection assay services focus on detecting and quantifying protein expression, modification and regulation. This is crucial for addressing key project questions related to mode-of-action, pharmacodynamic biomarkers and the efficacy of lead candidates. We offer a range of assay formats tailored to meet the specific needs of each of your projects and develop novel assays for unprecedented target proteins or their modifications. We utilise both traditional techniques, such as western blot and ELISA, and advanced methods like the Simple Western system, which provides an automated, quantitative and high-throughput approach to protein detection through capillary-based separation. Our services include: 

  • Simple Western automated Western Blot (certified service provider for ProteinSimple Jess instrument)
  • Western blot 
  • Simple Western (capillary-based separation of protein using the Simple Western system) 
  • In-cell Western (ICW) 
  • ELISA, MSD 
  • G-Lisa, HTRF assays, peptide arrays 
  • FACS 
  • Global proteomic studies (e.g., SILAC, iTRAQ multiplexing) 
  • High-content assays
  • Immunohistochemistry (IHC). 
     
 
 

Tailored next-generation sequencing services  

Our next-generation sequencing (NGS) services are customised to meet your specific needs, including experimental design, professional lab execution, in-house NGS sequencing and tailored bioinformatics analysis — all conducted at our Berlin site. We utilise state-of-the-art NGS technology to identify novel targets and analyse the mode-of-action of compounds with excellent resolution. Our 10x Genomics single-cell sequencing is particularly effective for measuring exploratory biomarkers in preclinical and clinical studies. Our services include: 

  • DNA and RNA isolation services 
  • Transcriptome sequencing (RNA-seq) 
  • Genome sequencing 
  • Exome sequencing 
  • Ribo-Seq 
  • SLAM-Seq 
  • High-throughput (DRUG-) seq 
  • Epigenetic profiling (ChiP-seq, methylome-seq, ATAC-seq) 
  • Amplicon and panel sequencing 
  • Barcode-seq (for CRISPR screening, AAV and LNP tissue distribution) 
  • 10x Genomics single-cell sequencing (scRNA-seq, scATAC-seq, T- and B-cell receptor profiling, CITE-seq, perturbation-seq, custom scAmplicon-seq).
 
 
 

Related topics & resources

3D rendering of an isolated proteasome with a ubiquitin-conjugated protein

Flyer: degrader platform

Nuvisan provides a fully integrated protein degradation platform encompassing comprehensive PROTAC® and molecular glue drug discovery services.

download
A computer screen showing histological microscopy image, auto imager in the background

Biomarker discovery

Advance precision medicine with Nuvisan’s expertise in biomarker discovery.  

learn more about Biomarker discovery

Contact us

Nuvisan is committed to protecting your privacy, and we'll only use your personal information to administer your account and to provide the products and services you requested from us. If you consent to us contacting you for this purpose, please tick below to say how you would like us to contact you:
You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Privacy Policy.

Email us

hello@nuvisan.com

Talk to us

talk icon
+49 731 9840 0 

Our locations

location icon

Neu-Ulm (headquarters)

Wegenerstrasse 13

89231 Neu-Ulm

Germany

Berlin

Muellerstrasse 178

13353 Berlin

Germany

Sophia Antipolis

2400 route des Colles

06410 Biot

France

Grafing

Am Feld 32

85567 Grafing

Germany

Waltrop

Im Wirrigen 25

45731 Waltrop

Germany

For concerns about pharmaceuticals or adverse drug-related events, contact us at: complaints@nuvisan.com