Immuno-oncology

Harnessing the immune system to battle cancer

Immuno-oncology (IO) research is a rapidly evolving field that focuses on harnessing the body's immune system to fight cancer. IO aims to enhance or manipulate the immune system’s natural ability to recognise and destroy cancer cells. Through innovative approaches such as immune checkpoint inhibitors, cancer vaccines and adoptive cell therapies, IO research holds great promise for improving patient outcomes, offering more targeted, less toxic treatments and providing new hope for individuals with difficult-to-treat cancers.  

Image showcasing antibody binding to human cell receptors 

Immuno-oncology solutions 

Nuvisan offers a broad portfolio and customised services to drive your immuno-oncology project forward. With our extensive industry experience, we advise on and perform studies that are ideally suited to advance your immuno-oncology program from the exploratory to the preclinical and clinical phases. 

MACS Quant Flow Cytometer in action

In vitro immuno-oncology solutions 

We offer tailored cell-based screening assays for novel immunotherapeutics, mechanism of action characterisation and the identification of new drug targets. Our team of experts provides guidance on the optimal strategy for advancing your compound from the lab to clinical application. Our services include: 

  • Access to fresh human blood panel 
  • Immune cell mediated tumor killing assays 
    • Natural killer (NK) cell tumor killing assays 
    • Cytotoxic T cell-mediated tumor killing assays (2D and 3D) 
    • Antibody-dependent cytotoxicity assays with macrophages, NK or T cells
  • T- cell exhaustion assays
  • Differentiation and stimulation assays
    • Tregs, Th17, Th1
    • Dendritic cells
    • B cell class switch
    • M1/ M2 macrophages
  • Migration, chemotaxis and phagocytosis assays
  • Tumor cell line assays
    • CRISPR-based screening, transcriptomics
    • Target expression analysis. 
 
LEARN MORE

In vivo immuno-oncology solutions  

We provide a robust portfolio of well-characterised cell line-derived syngeneic immuno-oncology models. These models are available with the option for in-depth analysis of key immune cell subsets, allowing for correlation with tumor progression. We also offer humanised models as a platform for evaluating the efficacy of therapies in human-like systems. 

  • Anti-tumor efficacy studies (including tolerability and exposure studies) 
  • Pharmacokinetic (PK) and pharmacodynamic (PD) assessments 
  • Humanised mouse models 
  • Cytokine and immuno-profiling employing spectral flow cytometry (>28 parameters) 
  • In vivo imaging (bioluminescence, µCT) 
  • Single-cell RNA sequencing  
  • Spatial profiling of tumor-infiltrating lymphocytes 
    • Single and multi-color fluorescent and chromogenic staining 
    • In situ hybridisation (RNAscope®).

 

LEARN MORE

Related topics & resources

Image depicting dendritic cell and T cell interaction

Immunology & inflammation

Explore the in vivo solutions we offer to support your research in the immunology and inflammation areas.

learn more about Immunology & inflammation
An intricate diagnostic interface displaying a full-body 3D scan and various health metrics

Therapeutic areas

Our team of experts supports you with cumstomised solutions for a wide range of therapeutic areas.

learn more about Therapeutic areas
Whole slide scanning of IHC staining

Our biomarker solutions

Explore our biomarker platform to drive your drug discovery and development efforts. 

learn more about Our biomarker solutions

Contact us

Nuvisan is committed to protecting your privacy, and we'll only use your personal information to administer your account and to provide the products and services you requested from us. If you consent to us contacting you for this purpose, please tick below to say how you would like us to contact you:
You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Privacy Policy.

Email us

hello@nuvisan.com

Talk to us

talk icon
+49 731 9840 0 

Our locations

location icon

Neu-Ulm (headquarters)

Wegenerstrasse 13

89231 Neu-Ulm

Germany

Berlin

Muellerstrasse 178

13353 Berlin

Germany

Sophia Antipolis

2400 route des Colles

06410 Biot

France

Grafing

Am Feld 32

85567 Grafing

Germany

Waltrop

Im Wirrigen 25

45731 Waltrop

Germany

For concerns about pharmaceuticals or adverse drug-related events, contact us at: complaints@nuvisan.com