In vivo models of immunology and inflammation
Acute inflammation models (PD models) – evaluate anti-inflammatory therapies with our robust acute models:
- LPS-induced peritonitis (mouse/rat)
- MDP-induced peritonitis (mouse/rat)
- Hapten-induced DTH response (mouse/rat).
Arthritis models – mimic chronic joint inflammation and tissue damage:
- Adjuvant-induced arthritis (rat)
- Collagen antibody-induced arthritis (mouse).
Respiratory models – address airway inflammation and pulmonary diseases:
- Eosinophilic asthma (HDM-induced; mouse)
- Mixed-granulocytic asthma (HDM/CFA-induced; mouse)
- Pulmonary fibrosis (Bleomycin-induced; mouse/rat).
Dermatology models – investigate inflammatory skin diseases:
- Contact dermatitis (DNFB, TMA, Oxazolone; mouse/rat)
- Croton oil-induced irritative dermatitis (mouse/rat)
- Imiquimod-induced psoriasis (mouse)
- Alopecia shaving/hair growth model (mouse)
- Ex vivo human skin explants.
Inflammation-related metabolism models – study inflammation in metabolic contexts:
- Diabetes models (mouse/rat)
- MASH liver inflammation (mouse/rat)
Inflammatory pain models – explore pain-relieving efficacy in inflammation model: dynamic weight bearing (DWB) in LPS-induced abdominal pain (rat).
In vivo services: In addition to efficacy and PK/PD evaluations, we offer histopathology assessments, in vivo imaging, biomarker analysis and immune profiling in various ex vivo tissues, optimally complementing your preclinical package in accordance with Good Clinical Practice (GCP).
