Biophysics Platform

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Our extensive Biophysics Platform comprises all state-of-the-art methods ranging from TSA, NanoDSF, SPR, NMR, MS, MST, ITC, DLS, CD-spectrometry* to characterize proteins, protein-SMOL interactions and protein-protein complexes. To support the lead finding and developing process we develop  individual tailor made assays for:

  • Hit Characterization (binding, kinetics, thermodynamic profiling)
  • Mode  of Action  ( e.g. cooperativity, competition)
  • Target Engagement
  • SAR Support
  • TSA Screen
  • Fragment Screening

 

*TSA – Thermal Shift Assay; NanoDSF – Nanoscale Differential Scanning Fluorimetry; SPR – Surface Plasmon Resonance; NMR – Nuclear Magnetic Resonance; MS – Mass Spectrometry; MST – Microscale Thermoporesis; ITC - Isothermal Titration Calorimetry; DLS – Dynamic Light Scattering; CD-Spectrometry – Circular Dichroism Spectrometry

 

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Bioanalysis
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(exploratory & GxP)

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