We offer world-leading expertise and capabilities to develop the optimal assays for your target, run the screening campaign in ultra-high-throughput and follow up the hits in lead optimization until the clinical candidate compound is identified.
Our portfolio contains biochemical, biophysical as well as cell- and phenotypic-based HTS compatible assay technologies.
We have more than 20 years of experience in designing screening campaigns to reliably identify the most effective and selective compounds for your target. The flexible setup of our automated liquid handling and uHTS systems (>150000 datapoints per day) allow us to run several screening campaigns in parallel and to adapt the workflows to the project’s needs.
We can screen large client’s compound libraries and have access to more than 3 million well-characterized compounds from Bayer's library to fuel your lead identification project's success. Our screener and medicinal chemists collaboratively evaluate the hit list to select the most promising candidates.
Our machine park includes several PHERAstar and ViewLux microplate readers with detection possibilities for a wide range of readout technologies, such as TR-FRET, fluorescence polarization, radioactivity and luminescence. Our biophysical platforms allow us to analyze Thermal Shift as well as Surface Plasmon Resonance Assays and to use the mass spectrometers RapidFire LC-ESI/MS and rapifleX MALDI-TOF/MS as plate readers.
We possess several High-Content Screening setups based on poly-automated confocal Opera Phenix systems as well as brightfield microscopes to support 2d, 3d and 4d cellular assays and screening campaigns. Polyautomated cell cultivation and liquid handling stations enhance our throughput capabilities. Our powerful IT infrastructure supports multiparametric image analysis and artificial intelligence based evaluation strategies.
We support hit-to-lead and lead optimization programs with a wide range of methods for compound characterization. Our very fast turnaround times of around one week from compound delivery to data report pave the way towards effective decision making based on comprehensive data sets in lead optimization cycles.
Among others, we have profound knowledge in high-throughput binding kinetic characterization, mode of action studies, protein degradation assays, Schild analysis, selectivity assessment and orthologs assays.