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We don’t just run your study. We make sure it’s the right one.

At Nuvisan, we design studies that drive confident decisions:
  • Need metabolism done right? Our purpose-built studies are designed to help find what matters. START HERE.
  • Want to simplify your DMPK journey? We offer custom DMPK programs managed from design to delivery. FIND OUT MORE.
  • Not sure what your PK data is telling you? We help you make sense of it. Get expert guidance to decode your data and plan next steps HERE.

Biotransformation and metabolite profiling – designed to deliver reliable data and authentic insights

Every compound is unique. So why settle for a one-size-fits-all approach? We tailor the study design according to your compound’s characteristics.

Why this matters

Missed metabolites can mean missed safety signals – and missed safety signals can delay development, trigger regulatory questions. That’s why our metabolism studies are designed to deliver robust detection – and to focus on what truly matters.

What sets us apart?
  • Intelligent in vivo metabolism studies with radiolabelled compound: Each study is designed using compound-specific PK parameters to optimise radioactive dosing and sampling intervals, helping ensure quantifiable radioactivity levels across key matrices. This approach is designed to maximise the chances of identifying all relevant metabolites and helps enable confident structure elucidation.
  • Enhanced sensitivity with offline radiodetection: Unlike standard online radiodetection, which often only captures major metabolites, our offline radiodetection method offers significantly higher sensitivity. This helps detecting minor and low-abundance metabolites – which can be reactive, toxicologically significant or flagged by regulators. Missing these metabolites isn’t just a technical gap – it’s a potential safety and regulatory risk.
  • Scientifically guided metabolite identification: We go beyond arbitrary thresholds by applying scientific judgment to guide metabolite identification. Using knowledge of likely biotransformation pathways and chemical structure, we focus on metabolites that are most likely to be relevant for safety and regulatory assessment. 

Simplify your DMPK journey today

We manage your full DMPK program – from design to delivery. 
One package. Four essential studies. Make more of your budget.

What’s included:

Tailored combinations of:

  • [¹⁴C] radiolabelling 
  • Interspecies comparison of in vitro metabolism 
  • Mass balance including bile and expired air
  • In vivo metabolite profiling and identification 
  • Tissue distribution by quantitative whole body autoradiography (QWBA)
  • Caco-2 permeability
  • In vitro drug-drug interactions (DDI) 
  • Plasma and/or tissue protein binding
  • Whole blood distribution
  • In vivo pharmacokinetics
  • Data interpretation by senior experts.
We offer a free 60-minute session with a DMPK expert for strategic input before you commit.

Not sure what your PK data is telling you?
We help you make sense of it.

Reserve your spot here and talk with a senior DMPK expert in a free 60-minute session.

What your session can include:
  • Walk through your current DMPK questions 
  • Help you prioritise what matters
  • Help you consider a path forward – or help you identify what may be missing 
  • Get high-level input on your data or study plans
  • Clarify key regulatory considerations or health authority questions
  • Get perspective before investing in a program
  • Plan your next study with expert input 
  • Start a conversation about deeper collaboration.

SCHEDULE MEETING

 
 
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