In vitro DMPK

In vitro DMPK for discovery

In vitro DMPK assays are essential in early drug discovery for evaluating the pharmacokinetic properties of potential candidates. These assays predict a drug's behaviour in the body by assessing its absorption, distribution, metabolism and excretion (ADME) characteristics. Cost-effective and time-efficient, in vitro methods allow for the screening of numerous compounds before advancing to in vivo studies. Our key assays include liver microsomal stability tests, cytochrome P450 enzyme assays for metabolic profiling, protein binding studies and permeability tests (e.g., Caco-2 cell model). This data guides chemical structure modifications to optimise bioavailability, reduce toxicity and improve efficacy. Our experienced PhD-level scientists have a strong understanding in interpreting results, integrating them into project contexts, and establishing structure–property relationships. We accommodate your needs, whether for screening services or the design, performance and evaluation of screening cascades. Our in vitro compound profiling services include assays for:

• Metabolic stability
• Drug-drug-interactions
• Metabolite ID
• Permeability and transporter
• Protein binding and blood partitioning