Understanding your lead candidate´s metabolism
At Nuvisan, we support metabolite profiling at all stages of your drug discovery projects. Understanding the metabolites of your drug molecule is crucial for interpreting data and optimising its pharmacological, pharmacokinetic and toxicological properties. Before full characterisation of your candidate across different species becomes critical, it is essential to assess the metabolic liabilities of your molecules. This early insight helps your chemists make informed decisions during the hit-to-lead and lead optimisation phases.
We assist you efficiently in identifying the metabolic soft spots of your molecules, helping provide insights into the structural elements that contribute to metabolic liabilities.
Our services include metabolic stability screening assays, custom-designed in vitro experiments and analysis of pharmacokinetic in vivo samples. We determine the metabolic soft-spot profile of your compound, offering structural elucidation of metabolites and proposed biotransformation reactions, focusing on the five most abundant metabolites.
For advanced projects, we provide in-depth characterisation of your molecule's metabolic profile, comparison of metabolites across species and identification of metabolites from in vivo pharmacokinetic studies in preclinical species.
