Nuvisan logo
  • contact us navContact Us
  • search navSearch
Let's connect

Want to discuss your project or have any questions?

PhysChem

Understanding drug properties

Physicochemical characterisation (PhysChem) is crucial for optimising drug candidates during discovery. Key properties like lipophilicity, solubility and stability provide insights into DMPK parameters such as permeability and bioavailability. These measurements are foundational for ADMET characterisation and are tailored to fit both the “rule of five” and beyond. In collaboration with our Digital Life Sciences unit, we help refine your compounds for successful development.

A rack of samples for HPLC analysis

Physicochemical characteriation (PhysChem)

Our advanced platforms offer a comprehensive range of services:

  • Lipophilicity assessment
    • High-throughput logD determination using HPLC-based systems.
  • Solubility screening
    • Rapid kinetic solubility assays (DMSO-based).
    • Thermodynamic solubility in biorelevant media (FaSSIF, FeSSIF, FaSSGF).
  • Stability studies
    • Degradation analysis in varying pH, heat, oxidative and gastric juice conditions.
    • Reactivity assessments for covalent binders (glutathione, cysteine).
  • Specialised characterisation
    • Crystallinity (XRPD) and polar surface area (EPSA)
    • Tailored packages for PROTAC®s, peptides and macrocycles.
These services ensure your drug candidates are optimised for in vivo studies and beyond.

Contact us

Nuvisan is committed to protecting your privacy, and we'll only use your personal information to administer your account and to provide the products and services you requested from us. If you consent to us contacting you for this purpose, please tick below to say how you would like us to contact you:
You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Privacy Policy.

Email us

hello@nuvisan.com

Talk to us

talk icon
+49 731 9840 0 

Our locations

location icon

Neu-Ulm (headquarters)

Wegenerstrasse 13

89231 Neu-Ulm

Germany

Berlin

Muellerstrasse 178

13353 Berlin

Germany

Sophia Antipolis

2400 route des Colles

06410 Biot

France

Grafing

Am Feld 32

85567 Grafing

Germany

Waltrop

Im Wirrigen 25

45731 Waltrop

Germany

For concerns about pharmaceuticals or adverse drug-related events, contact us at: complaints@nuvisan.com
 
v.1.1.1352