Isothermal titration calorimetry

Thermodynamic insights into molecular binding

Our experienced scientists leverage isothermal titration calorimetry (ITC) to provide you with direct insights into the thermodynamics of binding events. ITC uniquely determines key parameters – enthalpy (ΔH), entropy (ΔS), free energy (ΔG), steady-state affinity (KD) and stoichiometry – in a single experiment. Our experts offer precise analysis without requiring modifications to your molecules, using a broad range of buffer compositions to suit your specific needs. We support you in profiling hit clusters, stereoisomers and hit-to-lead projects, and in nominating hits for structural biology. Our team also characterises RNA–ligand binding through ITC.