Biophysics

Tailored biophysical methods for comprehensive drug discovery support

We work closely with you to determine the most suitable methods for your drug discovery project. Utilising a comprehensive range of biophysical techniques, we identify target engagement and validate hit lists. Furthermore, we offer complete kinetic and thermodynamic characterisation of novel compounds to support hit profiling, structure-activity relationships (SAR) and understanding their mode-of-action (MoA). Our biophysics team collaborates seamlessly with our protein sciences, screening, biochemistry and structural biology teams to ensure a holistic approach. Our experienced biophysicists provide access to a state-of-the-art biophysics toolbox, which includes:

• Surface plasmon resonance (SPR)
• Isothermal titration calorimetry (ITC)
• Thermal stability assays: intrinsic fluorescence (nanoDSF) and dye-based assays (DSF)
• Microscale thermophoresis (MST)
• Nuclear magnetic resonance spectroscopy (NMR)
• Mass spectrometry (MS)