Solid-state characterisation

Polymorphism 

Nuvisan offers polymorphism studies to optimise the solid-state properties of your APIs and formulations. Our expertise helps ensure the identification, characterisation and control of polymorphic forms to enhance drug stability, solubility and bioavailability. 

• Polymorphic screening: Systematic exploration of crystal forms under varied conditions. 
• Advanced analytical techniques: Utilising XRPD, DSC, and microscopy for precise characterisation.
• Form selection: Guidance on selecting the most suitable polymorph for formulation.
• Regulatory support: Comprehensive documentation to meet regulatory requirements.
• Integrated approach: Seamless collaboration with formulation development and manufacturing teams.

Nuvisan’s polymorphism expertise helps ensure robust and efficient development and achieve optimal product performance and regulatory success.

Salt screening

Nuvisan provides tailored salt screening studies to identify and optimise the most suitable salt form of your APIs. Our expertise helps ensure improved solubility, stability and manufacturability, to drive successful drug development. 

• Comprehensive screening: Evaluation of a wide range of counter-ions under diverse conditions.
• Advanced analytical techniques: Employing XRPD, NMR, DSC and solubility testing for thorough characterisation.
• Optimised selection: Identification of the best salt form based on desired properties like stability and bioavailability.
• Customised approach: Tailored strategies to align with your API’s unique requirements.
• Regulatory-ready data: Complete documentation to support regulatory submissions.

At Nuvisan, we combine scientific expertise with state-of-the-art technologies to deliver high-quality salt screening services, helping ensure your API achieves its full therapeutic potential. 

XRPD testing

Nuvisan specialises in X-ray powder diffraction (XRPD) analysis, offering precise insights into the crystalline structure of pharmaceutical compounds. Our XRPD services are essential for understanding material properties, ensuring quality and supporting regulatory requirements. 

We provide:

• Comprehensive differentiation and quantification of crystalline and amorphous phases
• Detailed detection and characterisation of polymorphic forms for optimal form selection
• Accurate determination of multi-phase mixture composition
• Thorough evaluation of crystalline structure changes under diverse conditions.

Leveraging our two advanced XRPD instruments, including a GMP-qualified system, and our experienced team, Nuvisan helps ensure reliable, high-quality results to drive your development projects forward.