Protein Technology

Our team has long-standing experience in the design of appropriate constructs for multi-domain and membrane proteins, followed by expression and purification to achieve high-quality proteins for crystallization and biophysical applications.

We have a holistic expertise in the application of biophysical methods for various applications including

• Surface Plasmon Resonance (SPR)
• (cellular) Thermal Shift Assays(TSA)
• Isothermal Titration Calorimetry (ITC)
• Differential Scanning Fluorimetry (DSF)
• Microscale Thermophoresis (MST)

We apply mass spectrometry-based methods to identify covalent binders to protein targets, to analyse binding of lead molecules to protein targets using native MS, and to assess the quality of protein batches.