Discovery Bioanalysis

Discovery bioanalysis focuses on the identification and quantification of drugs, metabolites, and proteins in biological systems. It plays a crucial role in drug development and biomarker discovery. The insights gained from our scientists in discovery bioanalysis can support you with solutions specifically tailored to your project needs—from target identification and validation all the way to lead optimization and in-depth characterizations of clinical candidates.

Welcome to Our DMPK Bioanalysis Services!

Optimize your molecule with our bioanalytical DMPK services that are designed to provide you with high-quality quantitation of drugs and their metabolites in various biological matrices. With decades of experience in discovery bioanalysis, our team of experts is committed to delivering accurate and precise results on schedule to support your drug discovery and development projects.

Our laboratories offer various analytical techniques, including liquid chromatography–tandem mass spectrometry (LC–MS/MS), to quantify drugs like protein targeting chimeras (PROTACs); small molecules obeying the extended rule of five; and macrocycles, peptides, and hormones in various biological matrices. In addition, we also provide quantitative analysis of endogenous metabolites (biomarkers) as targeted metabolomics approach in plasma, urine, tissues, and other biological matrices. Furthermore, expertise with multiple processing techniques, including protein precipitation, liquid–liquid extraction, solid-phase extraction, derivatization, and column switching, foster the development of the optimum method for meeting each project’s requirements. Our state-of-the-art equipment and technology ensure that our methods are reliable, sensitive, and specific, providing you with value-adding data. Of course, if requested, both the development and validation of bioanalytical methods are possible, according to guidelines in a variety of species and matrices from non-clinical studies.

Our DMPK discovery bioanalysis services can support the stages of drug discovery from lead confirmation and lead optimization to preclinical studies. We offer a comprehensive range of services, including pharmacokinetic (PK) and pharmacodynamic (PD) analysis, including metabolites, as well as toxicokinetic analysis. Our PK experts provide high-quality PK/PD assessments for every step, ranging from study preparation to report generation, with industry standard PK/PD analysis tools.

Our team of trained and skilled professionals work closely with you to design customized studies that meet your specific goals and timelines. We are committed to providing you with high-quality data and timely reports to support your drug discovery decisions. Our non-GLP DMPK services are available as an integrated drug discovery platform or as a stand-alone service. Ultimately, we are experienced in the analysis of samples from non-clinical studies, affording us the flexibility and capacity to meet your needs.