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Scale-up and advanced techniques

Scaling drug discovery

Scaling up compounds is a critical step in drug discovery, bridging small-scale synthesis and multi-kilogram production. At Nuvisan, we provide expertise in synthetic design, process optimisation and the application of advanced technologies to overcome challenges. With flexible solutions, state-of-the-art facilities and GLP-certified processes, we ensure your project is delivered efficiently and tailored to your requirements.

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Scale-up and advanced techniques

Our chemists combine scale-up expertise and advanced techniques to seamlessly transition your chemical projects from lab-scale to production. 

Scale-up expertise
  • Transition of compounds from milligrams to kilograms with route optimisation
  • Route scouting and safe reagent alternatives (e.g., pyrophoric substances)
  • Purification methods, that includes:
    • Recrystallisation, chromatography and high-throughput preparative HPLC
    • Chiral resolution for enantiomeric purity
    • Collaborative analysis with CoA certification to help ensure quality
    • Building block synthesis, toxicological batches and GMP manufacturing.
Advanced Techniques
  • Flow and photochemistry
    • Customised photoreactors for batch and flow (photoflow) modes
    • Controlled conditions for higher yields and shorter reaction times
    • Advanced flow chemistry to efficiently handle unstable intermediates.
  • High-pressure reactions
    • Gas reactions (e.g., hydrogenation) at up to 100 bar
    • Reaction scale-up  from milligrams to hundreds of grams
    • Parallelised chemistry for rapid optimisation and development.
  • Plate-based chemistry/direct-to-biology
    • Nano-scale synthesis of compound libraries on 96-well plates.

Contact us

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Talk to us

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+49 731 9840 0 

Our locations

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Neu-Ulm (headquarters)

Wegenerstrasse 13

89231 Neu-Ulm

Germany

Berlin

Muellerstrasse 178

13353 Berlin

Germany

Sophia Antipolis

2400 route des Colles

06410 Biot

France

Grafing

Am Feld 32

85567 Grafing

Germany

Waltrop

Im Wirrigen 25

45731 Waltrop

Germany

For concerns about pharmaceuticals or adverse drug-related events, contact us at: complaints@nuvisan.com