Scale-up and advanced techniques

Scale-up and advanced techniques

Our chemists combine scale-up expertise and advanced techniques to seamlessly transition your chemical projects from lab-scale to full-scale production. 

• Transition of compounds from milligrams to kilograms with route optimisation
• Route scouting and safe reagent alternatives (e.g. pyrophoric substances)
• Purification methods, that includes:
  • Recrystallisation, chromatography and high-throughput preparative HPLC
  • Chiral resolution for enantiomeric purity
  • Collaborative analysis with certification of analysis (CoA) to maintain quality standards
  • Building block synthesis, toxicological batches and GMP manufacturing.

• Customised photoreactors for batch and flow (photoflow) modes
• Precisely controlled reaction conditions for higher yields and reduced reaction times
• Advanced flow chemistry to efficiently handle unstable intermediates.

High-pressure reactions

• Gas reactions (e.g. hydrogenation) at up to 100 bar
• Reaction scale-up  from milligrams to hundreds of grams
• Parallel chemistry for rapid optimisation and development.

Direct-to-biology (D2B)

• Plate-based synthesis of compound libraries with thousands of members
• Several well-established chemical transformations
• Rapid quality control (QC) of unpurified compounds prior to in-house or at-client testing.