In vivo ADME in Discovery, Early Development & Development


RODENTS (Rats/Mice)

Species

Endpoints

PK Studies

Single dose screening PK (cassette or mono),
including analysis of urine/feces

 

PK in genetically engineered models
(metabolism/transporter)

 

PK regulatory (single or repeated dose)

 

PK in the presence of inhibitors ,
in vivo DDI

ADME studies

Radio AME (inc. bile)*

 

QWBA, microautoradiography*

 

Entero-hepatic cycle* **

 

Tissue Distribution by "cut and count"

 

Brain distribution

* Requires radiolabel
** performed by 3rd party provider

 


NON-RODENTS

Species

Endpoints

Non-Rodend
(dog)

Single dose screening PK
(cassette or mono),
including analysis of urine/feces

 

PK regulatory (single or repeated dose)

 

Radio AME study *

 

PK in the presence of inhibitors
of enzymes or transporters

 

in vivo DDI

* Requires radiolabel

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