In vitro ADME in Early Development & Development


METABOLISM AND CYP INTERACTIONS

Test System

Endpoints

Microsomes

Clearance/metabolite
profile+identification

 

CYP phenotyping

 

CYP inhibition

Recombinant Enzymes

Phenotyping

 

KM/Vmax

Hepatocytes

Metabolite profile,
interspecies - cold

 

Metabolite profile,
interspecies - labelled

 

Intrinsic clearance

 

CYP phenotyping

1

Inhibition non-CYP

1

Enzyme induction*

* 3rd party supplier

 

ABSORPTION, DISTRIBUTION AND TRANSPORT (INCL. DDI)

Test System

Endpoints

Plasma Protein

Binding (ultrafiltration, equilibrium dialysis)

 

Identification of binding partners

 

Displacement

Whole blood

Blood-to-plasma distribution

CaCo-2

Permeability

 

Transporters (Pgp, BCRP), Substrate

 

Transporters (Pgp, BCRP), Inhibitor

Recombinant Transporters*

Substrate, Inhibition

Hepatocytes

Uptake

* 3rd party supplier

Contact

Business Development
Please send us an Email!



Exhibitions

EBD
Bio Europe Spring
25.03 - 27.03.2019
Vienna / Austria


Euro Biosimilars
12th European Biosimilars Congress
15.04 - 16.04.2019
Berlin / Germany


Swiss Biotech
Swiss Biotech Day 2018
07.05.2019
Basel / Switzerland