In vitro ADME in Early Development & Development


METABOLISM AND CYP INTERACTIONS

Test System

Endpoints

Microsomes

Clearance/metabolite
profile+identification

 

CYP phenotyping

 

CYP inhibition

Recombinant Enzymes

Phenotyping

 

KM/Vmax

Hepatocytes

Metabolite profile,
interspecies - cold

 

Metabolite profile,
interspecies - labelled

 

Intrinsic clearance

 

CYP phenotyping

1

Inhibition non-CYP

1

Enzyme induction*

* 3rd party supplier

 

ABSORPTION, DISTRIBUTION AND TRANSPORT (INCL. DDI)

Test System

Endpoints

Plasma Protein

Binding (ultrafiltration, equilibrium dialysis)

 

Identification of binding partners

 

Displacement

Whole blood

Blood-to-plasma distribution

CaCo-2

Permeability

 

Transporters (Pgp, BCRP), Substrate

 

Transporters (Pgp, BCRP), Inhibitor

Recombinant Transporters*

Substrate, Inhibition

Hepatocytes

Uptake

* 3rd party supplier

Contact

Business Development
Please send us an Email!



Exhibitions

CURIOUS 2018
Future Insight Conference
16.07. - 18.07.2018
Darmstadt / Germany


CPhI Korea
Mix the world of Pharma products, People & solutions
28.08. - 30.08.2018
Seoul / South Korea


BioFit
7th edition
Fostering Innovation & Transfer
04.12. - 05.12.2018
Lille / France